Effects of Ethanol Extract of Unripe Annona muricata (l.) Fruits on the Haematological and Histopathological Parameters in Swiss Albino Rats Infected with Salmonella typhi
| Autor: | Olajide Sunday Faleye, Ebenezer Oluyemi Dada |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
biology
Traditional medicine business.industry Lymphocyte Spleen General Medicine biology.organism_classification Salmonella typhi Ciprofloxacin 03 medical and health sciences Red blood cell 0302 clinical medicine medicine.anatomical_structure 030202 anesthesiology Toxicity Red pulp Medicine business Annona muricata 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | British Journal of Pharmaceutical Research. 9:1-13 |
| ISSN: | 2231-2919 |
| DOI: | 10.9734/bjpr/2016/19971 |
| Popis: | Background: In addition to the problems of resistance to commonly used antibiotics, toxicity depicts the state of adverse effects caused by the interaction of toxicants with cells. Similarly, blood components are exposed to significant concentrations of toxic compounds as they form the medium for their transport. Aims: To study the effects of ethanol extract of unripe Annona muricata fruits on the haematological and histopathological parameters in Swiss albino rats infected with Salmonella typhi. Place and Duration of Study: Department of Microbiology Laboratory, Federal University of Technology, Akure, Ondo State, Nigeria, between June 2014 and December 2014. Methodology: Matured unripe fruits of A. muricata were collected, dried, powdered and extracted using 70% ethanol. Eighteen rats of same age between 170-220 g in weight were selected and divided into six groups containing three each. The infectivity dose (ID) was determined using the clinical Salmonella typhi obtained from Don Bosco Catholic Hospital, Akure. The dose of the A. muricata fruit extract (400 mg/kg) used in this study was administered orally for 7 days. At the end of the treatment period, the rats were fasted overnight. Then blood samples were collected by cardiac puncture for haematological studies and there after sacrificed. Organs (liver, heart, kidney and spleen) were excised for relative organ weight analysis and histopathological studies. Results: The infectious dose (ID) of S. typhi on experimental rats in this study was 6.8x106 cfu/ml while the weights of liver, heart and spleen in all groups were not significantly different from the control. However, a significant increase in the heart was observed in group given the extract and antibiotics (ciprofloxacin). The Packed Cell Volume (PCV) and Haemoglobin (Hb) of rats treated with extract and ciprofloxacin increased significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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