GABAergic attenuation of cocaine-induced dopamine release and locomotor activity

Autor:	Stephen L. Dewey, Nora D. Volkow, Simone P. Porter, Chandra S. Chaurasia, Jonathan D. Brodie, Nicole B. Russo, Joanna S. Fowler, Francis A. Clarkson, Dina Tedeschi, Chu-En Chen, David Alexoff, Rona M. Straughter-Moore
Rok vydání:	1997
Předmět:	Microdialysis medicine.drug_class Chemistry Lorazepam Striatum Pharmacology Nucleus accumbens Cellular and Molecular Neuroscience Dopamine Sedative Sedative/hypnotic medicine GABAergic medicine.drug
Zdroj:	Synapse. 25:393-398
ISSN:	1098-2396 0887-4476
DOI:	10.1002/(sici)1098-2396(199704)25:4<393::aid-syn11>3.0.co;2-w
Popis:	GABA modulates dopamine concentrations in the nucleus accumbens and corpus striatum. Using in vivo microdialysis techniques we examined this modulatory role and the extent to which three different GABAergic drugs can attenuate cocaine's ability to increase extracellular dopamine concentrations and gross locomotor activity. Ethanol, lorazepam (Ativan), and gamma-vinyl GABA (GVG) significantly and dose-dependently attenuated cocaine-induced dopamine release in the corpus striatum of freely moving animals. Unlike ethanol or lorazepam, however, GVG is not a sedative hypnotic in the doses used, and hence the strategy of selectively increasing GABAergic activity by suicide inhibition of the catabolic enzyme, GABA-transaminase, offers the unique advantage of attenuating cocaine-induced dopamine release without the apparent side effects typically associated with sedative hypnotics.
Databáze:	OpenAIRE
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