Cisplatinum and interstitial laser therapy for advanced head and neck cancer: A preclinical study

Autor: Marcos B. Paiva, Romaine E. Saxton, Quinten M. Vanderwerf, Dan J. Castro, Theodore S. Bell, Ines P. Graeber, J. Feyh, Adrien A. Eshraghi
Rok vydání: 1997
Předmět:
Zdroj: Lasers in Surgery and Medicine. 21:423-431
ISSN: 1096-9101
0196-8092
DOI: 10.1002/(sici)1096-9101(1997)21:5<423::aid-lsm3>3.0.co;2-s
Popis: Background and Objective Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA). Study Design/Materials and Methods Human SCCA tumors were grown as sc transplants in nude mice and injected with CDDP (0.4–1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300J). Results Tumors injected with CDDP epi-gel exhibited a partial response with 2–4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone. Conclusion These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer. Lasers Surg. Med. 21:423–431, 1997. © 1997 Wiley-Liss, Inc.
Databáze: OpenAIRE
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