Gross pathologic types of hepatocellular carcinoma in Italian patients: Relationship with demographic, environmental, and clinical factors

Autor: Paolo Caraceni, Giuseppe Francesco Stefanini, Giovanni Gasbarrini, Alighieri Mazziotti, Lorenzo Fornalè, Paolo Amorati, Mauro Bernardi, Giuseppe Gozzetti, Franco Trevisani, Gian Luca Grazi, Vincenzo Arienti, Paola Emanuela D'Intino
Rok vydání: 1993
Předmět:
Zdroj: Cancer. 72:1557-1563
ISSN: 1097-0142
0008-543X
Popis: Background. The prevalence of the different hepatocellular carcinoma (HCC) macroscopic types, and the association between these types and age, gender, blood group, alcohol and coffee intake, smoking habit, hepatitis virus markers, underlying cirrhosis, and cancer histologic type were retrospectively assessed in 416 unselected patients (321 with cirrhosis), Methods. The gross pathologic types of HCC were assessed by ultrasonography combined, in most cases, with computed tomography and angiography. Results. Solitary HCC was the most common cancer type (54.8%), followed by the multinodular (31%), diffuse (7.7%), and massive (6.5%) types. Cirrhosis and blood group other than 0 were independent risk factors for multinodular HCC (relative risk [RR] 1.6, P < 0.05; and RR 1.7, P < 0.005, respectively); the absence of cirrhosis and a heavy smoking habit were risk factors for the massive type (RR 4.9, P < 0.001; and RR 3.3, P < 0.01, respectively); and blood group 0 for the solitary type (RR 1.4, P < 0.001). The prevalence of highly undifferentiated cells increased as the tumor size did, so that grade IV cell atypia was associated with massive size of the carcinoma (P < 0.05). In cirrhotic patients, advanced liver dysfunction was associated with diffuse HCC (P < 0.05). As far as solitary HCC is concerned, the tumor size was greater in noncirrhotic than in cirrhotic patients (7 k 0.4 cm versus 4.8 f 0.15, P < 0.001). Conclusions. In Italian patients, HCC presents most frequently as a solitary nodule. The presence or absence of cirrhosis, blood group, and smoking habit can influ
Databáze: OpenAIRE
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