Application of a Microfluidic-Based Model of a Human Prostate Gland for Cancer Research

Autor:	Sander B. Frank, Fernando Ivich, Cindy K. Miranti, Yitshak Zohar, Meagan Tran, Andrew S. Kraft, Linan Jiang, Shekha Tahsin
Rok vydání:	2018
Předmět:	0301 basic medicine Stromal cell Kinase PIM1 Biology medicine.disease Human prostate Epithelium 03 medical and health sciences Prostate cancer 030104 developmental biology medicine.anatomical_structure Stroma Cancer research medicine Epithelial cell differentiation
Zdroj:	2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED).
DOI:	10.1109/nanomed.2018.8641586
Popis:	A Microfluidic-based model of a human prostate gland has been developed featuring a 3D co-culture of epithelial and stromal cells. The model was used to investigate the effects of normal stroma on normal luminal epithelial cell differentiation, and to measure the ability of cancerous epithelium to convert normal stroma to cancer stroma. The ability of PIM1 kinase to induce cancer stroma was also tested in the model. The results demonstrate a promising potential of the model for cancer research applications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::74f088119d0b2bdafb27cfd6fb61e216 https://doi.org/10.1109/nanomed.2018.8641586 Zobrazit plný text záznamu