Switch From Epoetin Beta to Darbepoetin Alfa Treatment of Anemia in Taiwanese Hemodialysis Patients: Dose Equivalence by Hemoglobin Stratification
| Autor: | Cheng-Chieh Hung, Chien-Hsing Wu, Chiao-Yin Sun, Chih-Chao Yang, Chien-Te Lee, Chih-Hsiung Lee, Jin-Bor Chen, Ben-Chung Cheng, Chun-Liang Lin, Chin-Chan Lee, Shang-Chih Liao |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Epoetin beta Darbepoetin alfa Anemia business.industry medicine.medical_treatment 030232 urology & nephrology Hematology 030204 cardiovascular system & hematology medicine.disease Gastroenterology Study duration 03 medical and health sciences 0302 clinical medicine Multicenter study Nephrology Internal medicine medicine Hemodialysis Hemoglobin business Intensive care medicine medicine.drug |
| Zdroj: | Therapeutic Apheresis and Dialysis. 20:400-407 |
| ISSN: | 1744-9979 |
| Popis: | This multicenter study was designed to assess the hemoglobin (Hb) stability and conversion ratio of the switch from epoetin beta to darbepoetin alfa in Taiwanese hemodialysis (HD) patients. A total of 135 HD patients were enrolled and randomized with intravenous darbepoetin alfa or epoetin beta. The study duration was 24 weeks. Equivalent doses and conversion ratios were assessed with respect to Hb stratification: low Hb (≥8.0 g/dL to ≤10.0 g/dL) and high Hb (>10.0 g/dL to ≤11.0 g/dL). The results showed stable Hb levels in the study period. At week 24, the conversion ratio was higher for high Hb than low Hb (296.4 IU/dose epoetin beta: 1 µg/dose darbepoetin alfa. vs. 277.2 IU/dose epoetin beta: 1 µg/dose darbepoetin alfa). In conclusion, the conversion ratio in the present study was higher than 1 µg: 200 IU for darbepoetin alfa: epoetin for treating anemia in Taiwanese HD patients. |
| Databáze: | OpenAIRE |
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