Cancer of Unknown Primary: Opportunities and Challenges

Autor:	Vikas Asati, Linu Abraham Jacob, D. Lokanatha, Govind Babu, Suresh Babu, K C Lakshmaiah, A H Rudresh, L K Rajeev, K N Lokesh
Rok vydání:	2018
Předmět:	Oncology 0303 health sciences medicine.medical_specialty business.industry Review article 03 medical and health sciences 0302 clinical medicine Cancer of unknown primary 030220 oncology & carcinogenesis Internal medicine Pediatrics Perinatology and Child Health medicine Immunohistochemistry business Pathological 030304 developmental biology
Zdroj:	Indian Journal of Medical and Paediatric Oncology. 39:219-226
ISSN:	0975-2129 0971-5851
Popis:	Cancer of unknown primary (CUP) is defined as histologically proven metastatic tumors whose primary site cannot be identified during pretreatment evaluation. Among all malignancies, 3%–5% remained as CUP even after the extensive radiological and pathological workup. Immunohistochemistry and molecular gene expression tumor profiling are being utilized to predict the tissue of origin. Unfortunately, the survival of these patients remains poor (6–9 months) except in 20% of patients who belong to a favorable subset (12–36 months). There is a need to understand the basic biology and to identify the molecular pathways which can be targeted with small molecules. This article reviews our current approach as well as treatment evolution occurred in the past three decades.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::74ed27cacdb6e0c6d65c87e1f720d3ac https://doi.org/10.4103/ijmpo.ijmpo_91_17 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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