NT-proBNP y desplazamiento del plano auriculoventricular. Relación e implicaciones diagnósticas
| Autor: | Raquel Cortés, Vicente Bertomeu, Miguel Rivera, Francisco Marín, R. Talens, Alejandro Jordán, Fernando García de Burgos, Juan Cosín, Vicente Mora, José L. Diago, Jose Leandro Perez Bosca, Antonio Salvador, Araceli Frutos, Vicente Miró, Rafael Payá, Francisco Sogorb, Vicente Climent |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Percentile education.field_of_study Ventricular function medicine.diagnostic_test business.industry Population Doppler echocardiography medicine.disease Surgery Clinical Practice Quartile Internal medicine Heart failure medicine Cardiology Population study cardiovascular diseases Cardiology and Cardiovascular Medicine business education |
| Zdroj: | Revista Española de Cardiología. 56:1043-1049 |
| ISSN: | 0300-8932 |
| DOI: | 10.1016/s0300-8932(03)77013-4 |
| Popis: | Introduction and objectives. NT-proBNP is useful in the diagnosis of heart failure and ventricular dysfunction. Left atrioventricular plane displacement (AVPD) is a consolidated index of ventricular function. Our objective was to carry out a multicenter population-based study to establish the relationship between plasma NT-proBNP levels with AVPD values. Patients and method. We studied 215 subjects (age 66 ± 9 years; 57.7% women) chosen from a random sample of 432 people from the Community of Valencia, who previously reported suffering from some degree of dyspnea. Doppler echocardiography was done, AVPD was calculated and plasma NT-proBNP concentrations were determined. All studies were completed in 194 patients. Results. For the whole population NT-proBNP was 88 (02,586) pg/ml and AVPD was 11.9 ± 1.6 mm. NT-proBNP concentration correlated well with AVPD (r = 0.44; p < 0.00001), and higher peptide levels were obtained in AVPD quartiles that indicated less displacement (p < 0.05). When NT-proBNP values were grouped according to their association with AVPD lower or higher than the 50th percentile AVPD, the difference was significant at p < 0.01. When AVPD values lower and higher than 10 mm were compared, NT-proBNP values were higher in persons with AVPD lower than 10 mm (p < 0.05). Conclusions. This population study found higher NTproBNP concentrations in subjects with lower AVPD, and illustrates the potential diagnostic usefulness of NTproBNP in clinical practice. |
| Databáze: | OpenAIRE |
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