On the cytotoxicity of a cationic tertiary amine PEGylated nanogel as nanocarrier for anticancer therapies
| Autor: | Alexei F. Licea-Navarro, Lizbeth A. Manzanares-Guevara, Angel Licea-Claverie, Irasema Oroz-Parra |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Tertiary amine technology industry and agriculture Cationic polymerization 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Methacrylate 01 natural sciences 0104 chemical sciences Colloidal gold PEG ratio General Materials Science Nanocarriers 0210 nano-technology Cytotoxicity Nanogel Nuclear chemistry |
| Zdroj: | MRS Communications. 8:1204-1210 |
| ISSN: | 2159-6867 2159-6859 |
| Popis: | Cationic PEGylated nanogels based on poly(N,N-diethylaminoethyl methacrylate) (PDEAEM) were prepared varying the ratio of PDEAEM to polyethyleneglycol (PEG), the initiator, and the crosslinker; resulting in nanogels of different surface charge (zeta-potential) and hydrodynamic diameter. Nanogels without PEG (100% PDEAEM) and nanogels containing 45 wt.% of PDEAEM were cytotoxic to human colon cancer cell line (HCT-116). Nanogels containing 20 wt.% or less of PDEAEM provided with a PEG shell were non-cytotoxic even at a concentration of 1 mg/mL. These nanogels loaded with 5-fluorouracil turned to be cytotoxic provoking cell death by apoptosis. Nanogels were also studied loaded with gold nanoparticles. |
| Databáze: | OpenAIRE |
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