Serum selenium levels and blood glutathione peroxidase activities in vitiligo
| Autor: | David Gaze, A Panske, E Panzig, Wayne D. Beazley, Karin U. Schallreuter |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
inorganic chemicals
chemistry.chemical_classification medicine.medical_specialty biology Glutathione peroxidase food and beverages chemistry.chemical_element Dermatology Vitiligo Metabolism medicine.disease chemistry.chemical_compound Endocrinology Enzyme chemistry Catalase Internal medicine biology.protein medicine Hydrogen peroxide Selenium Peroxidase |
| Zdroj: | British Journal of Dermatology. 141:301-303 |
| ISSN: | 0007-0963 |
| DOI: | 10.1046/j.1365-2133.1999.02980.x |
| Popis: | It has recently been shown that patients with vitiligo can accumulate epidermal hydrogen peroxide (H2O2) in association with low catalase levels. This study examined serum selenium levels and blood glutathione peroxidase activities in 61 patients and controls. The results showed high serum selenium levels in 56% of the patients. As at least one isoform of glutathione peroxidase requires selenium for its activity, enzyme activities were also evaluated. The overall results were not significantly different compared with controls, but further age-related analysis of the data indicated significantly lower activities in patients up to 46 years. As glutathione peroxidase can also efficiently degrade H2O2, the results of this study could indicate an additional impaired H2O2 metabolism in vitiligo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text