Investigation of the Relationship between Breast Cancers and HPVs
| Autor: | Mervat Saeed, Zehra Bozdağ, Yasemin Zer |
|---|---|
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Universal Journal of Clinical Medicine. 6:1-9 |
| ISSN: | 2331-9623 2331-964X |
| DOI: | 10.13189/ujcm.2018.060101 |
| Popis: | High-risk human papillomaviruses (HR-HPVs) have been implicated in the aetiology of a variety of human cancers, including cervical, colorectal, and head and neck (HN); also, (HPVs) may be important risk factors for breast carcinogenesis and metastasis. Previous studies that evaluated the prevalence of HPVs in breast cancer have generated considerable controversy. Based on this hypothesis, we aimed to investigate the prevalence of HPV infection in invasive breast cancer tissues. Our study included 80 paraffin blocks taken from breast cancerous tissue specimens of Turkish female patients and 13 controls (cervical cancerous tissue specimens) in Research and Practice Hospital- Sahinbey -Gaziantep University, using PCR (HPV Genotypes 14 Real-TM Quant / Italy) to detect the HR-HPV DNA. In our results: HR-HPV DNA was evidenced in (10%) of the breast cancer and in (92.3%) of the controls (p < 0.05). HPV (45-56-68) were the most prevalent genotypes in breast cancer cases. Also HPV co-infection was high (75%) in positive breast cancerous samples. Our data propose Human papilloma viruses may play a role as a possible causal relationship, or mediation or even as a cofactor in the development of some types of breast cancer, this still needs to be confirmed by prospective studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|