PLGA nanoparticles loaded with quaternary ammonium silane and riboflavin for potential applications in adhesive dentistry
| Autor: | Amr S. Fawzy, Umer Daood, Mallikarjuna Rao Pichika, Marrwa A Ibrahim, Kit-Kay Mak, Meera Priyadarshini Balasankar |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Polymers and Plastics Bond strength General Chemical Engineering technology industry and agriculture Nanoparticle 030206 dentistry 02 engineering and technology 021001 nanoscience & nanotechnology Silane Biomaterials 03 medical and health sciences chemistry.chemical_compound symbols.namesake 0302 clinical medicine chemistry Chemical engineering Zeta potential symbols Liberation Ammonium Adhesive 0210 nano-technology Raman spectroscopy |
| Zdroj: | International Journal of Adhesion and Adhesives. 105:102797 |
| ISSN: | 0143-7496 |
| DOI: | 10.1016/j.ijadhadh.2020.102797 |
| Popis: | Aim Novel k21 PLGA nanoparticles (nano-PLGA-RF/VE-TPGS0.50⁞k21) with synergistic effect of VE-TPGS with riboflavin-5-phospshate solution were used to analyze structural integrity, chemical interactions, antimicrobial resistance, mechanical properties as a delivery tool to acid-demineralized dentine-substrates. Materials and methods Synthesized spherical nano-PLGA ⋮ RF/VE-TPGS0.50⁞k21 were assessed for drug-encapsulation and release, antibacterial-profile, MTT, molecular simulation for MMP-2 and MMP-9 and Raman spectroscopy. Results k21 favoured increase in colloidal-size with positive zeta potential. Bands indicated k21 entrapment as nanoparticles were confined inside tubules with no effect on μTBS. XP-GScores were −2.383 and −4.383 for MMP-2 and -9. HYP liberation recorded with collagenase degradation resistance in nano-PLGA ⋮ RF/VE-TPGS0.50⁞k21 specimens. Conclusion Nano-PLGA ⋮ RF/VE-TPGS0.50⁞k21 specimens exhibited superior antibacterial/antibiofilm effects against cariogenic biofilms after bonding-resins infiltration without adversely affecting bond strength. |
| Databáze: | OpenAIRE |
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