Comparative anti-MRSA activities of seven selected Nigerian medicinal plants and phytochemical constituents of Piper guineense (Schum and Thonn.), Curculigo pilosa (Schum and Thonn.) and Chromolaena odorata (King and Robinson)

Autor:	Matthias Ikenna Agba, Buniyamin Adesina Ayinde, Maureen Uchechukwu Okwu, Henry Osamuyi Umumarongie, Tonye Grace Okorie
Rok vydání:	2014
Předmět:	biology Traditional medicine Phytochemical Ageratum conyzoides Peperomia pellucida Ocimum gratissimum Chromolaena odorata Bryophyllum pinnatum Medicinal plants biology.organism_classification Piper guineense
Zdroj:	IOSR Journal of Pharmacy and Biological Sciences. 9:07-13
ISSN:	2278-3008 2319-7676
Popis:	The aims of this study were to compare the anti-MRSA activities of Ageratum conyzoides, Bryophyllum pinnatum, Piper guineense, Peperomia pellucida, Ocimum gratissimum, Chromolaena odorata and Curculigo pilosa and to determine the phytochemical constituents of the bioactive plants. Preliminary antibacterial susceptibility test using 25mg/ml and 50mg/ml concentrations of the aqueous and ethanolic extracts of the plants on eight clinical MRSA isolates showed no anti-MRSA activity with A. conyzoides, B. pinnatum, P. pellucida and O. gratissimum. Activities were recorded with C. odorata, P. guineense and C. pilosa. Phytochemical analysis of the aqueous, ethanolic and hexane extracts of the three bioactive plants selected revealed the presence of: carbohydrates, reducing sugars, saponins, tannins, alkaloids, flavonoids and steroids while in the hexane extracts only steroids were obtained. Antibacterial activities of the aqueous, ethanolic and hexane extracts of the three plants on seven MRSA and four MSSA were: C. odorata: 9.29 ±1.25mm (MIC, 12.5mg/ml), 12.17 ±1.38mm (MIC, 12.5mg/ml), 5.06 ±1.17mm (MIC, 25mg/ml); P. guineense: 1.53 ±0.59mm (MIC, 50mg/ml), 6.34 ±1.19mm (MIC, 25mg/ml), 3.41 ±1.03mm (MIC, 12.5mg/ml) and C. pilosa: 2.14 ±0.69mm (MIC, 50mg/ml), 1.72 ±0.60mm (MIC, 50mg/ml) with no activity for its hexane extract respectively. The results suggest the need to isolate and evaluate the active constituents of C. odorata as the most efficacious plant for the development of novel chemotherapeutic agents for the effective treatment of MRSA infections.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::74d0a0479df3b32d839af4af21fd8cb9 https://doi.org/10.9790/3008-09560713 Zobrazit plný text záznamu