| Autor: |
Alexa J. Roeder, Megan A. Koehler, Sergei Svarovsky, Paniz Jasbi, Alim Seit-Nebi, Maria J. Gonzalez-Moa, John Vanderhoof, Davis McKechnie, Baylee A. Edwards, Douglas F. Lake |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.03.03.22270812 |
| Popis: |
BackgroundVaccination with COVID-19 mRNA vaccines prevent hospitalization and severe disease caused by wildtype SARS-CoV-2 and several variants, and likely prevented infection when serum neutralizing antibody (NAb) titers were >1:160. Preventing infection limits viral replication resulting in mutation, which can lead to the emergence of additional variants.MethodsDuring a longitudinal study to evaluate durability of a three-dose mRNA vaccine regimen (2 primary doses and a booster) using a rapid test that semi-quantitatively measures NAbs, the Omicron variant emerged and quickly spread globally. We evaluated NAb levels measured prior to symptomatic breakthrough infection, in groups infected prior to and after the emergence of Omicron.ResultsDuring the SARS-CoV-2 Delta variant wave, 93% of breakthrough infections in our study occurred when serum NAb titers were DiscussionThese results indicate that high titers of NAbs elicited by currently available mRNA vaccines do not protect against infection with the Omicron variant, and that mild to moderate symptomatic infections did occur in a vaccinated and boosted population, although did not require hospitalization. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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