| Autor: |
null Gregory Russell-Jones, null Kirsten McTavish, null John McEwan, null Bruce Thurmond |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Journal of Cancer Research Updates. 1:203-211 |
| ISSN: |
1929-2279 |
| DOI: |
10.6000/1929-2279.2012.01.02.6 |
| Popis: |
Many different types of tumour have previously been shown to over-express cell-surface receptors involved in the uptake of Vitamin B12 (VB12). We have examined the potential of using VB12 as a targeting agent for the delivery of pHPMA-conjugated daunomycin in four murine tumour models. VB12-targeted-duanomycin-HPMA conjugates were found to increase both the number of survivors and the survival time of tumour-bearing mice. The data indicate that VB12 may be highly effective in enhancing the efficacy of polymer-bound cytotoxins, particularly in those tumours that over-express receptors involved in vitamin B12 uptake. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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