Atrial Fibrillation After Coronary Artery Bypass Surgery: Can Ivabradine Reduce Its Occurrence?
Autor: | Wail Nammas, Zainab Abdel-Salam |
---|---|
Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
business.industry Atrial fibrillation Perioperative 030204 cardiovascular system & hematology medicine.disease Intensive care unit law.invention Coronary artery disease 03 medical and health sciences Coronary artery bypass surgery 0302 clinical medicine Bisoprolol law Physiology (medical) Internal medicine Ambulatory medicine Cardiology 030212 general & internal medicine Cardiology and Cardiovascular Medicine business Ivabradine medicine.drug |
Zdroj: | Journal of Cardiovascular Electrophysiology. 27:670-676 |
ISSN: | 1045-3873 |
DOI: | 10.1111/jce.12974 |
Popis: | INTRODUCTION We compared the efficacy of perioperative ivabradine, bisoprolol, or both for prevention of postoperative atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting (CABG). METHODS AND RESULTS We enrolled 740 consecutive patients scheduled for elective CABG with/without valve surgery. Patients were assigned to 1 of 3 protocols: ivabradine given perioperatively (48 hours preoperatively, then 1 week postoperatively) 5 mg bid for 24 hours, then 7.5 mg bid thereafter in patients who can tolerate (group 1, n = 212); bisoprolol given perioperatively 5 mg bid (group 2, n = 288); or both drugs given perioperatively (ivabradine as before + bisoprolol 5 mg once daily) (group 3, n = 240). Cardiac rhythm was continuously monitored for 15 days postoperatively by ambulatory event recorder. Clinical follow-up for the occurrence of arrhythmias was performed for the next 15 days. The primary endpoint was the incidence of AF at 30-day follow-up. Mean age was 56.5 ± 8.9 years (30.5% females). All patients completed 30-day follow-up. AF occurred in 10.4%. The 3 groups were matched for most baseline characteristics, echocardiographic and angiographic data (P > 0.05 for all). The incidence of AF was significantly lower in group 3 (4.2%), compared with group 1 (15.5%), and group 2 (12.2%), (P < 0.001 both). The duration of stay in the intensive care unit was shorter in group 3 versus group 1 and 2 (P < 0.001 both). CONCLUSION In patients undergoing elective CABG, adding ivabradine to β-blockers during the perioperative period was associated with reduced incidence of AF at 30-day follow-up, compared with either medication alone. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |