479 Safety and effectiveness of left atrial appendage occlusion in patients with chronic kidney disease

Autor: Michele Magnocavallo, Domenico Giovanni Della Rocca, Carlo Lavalle, Cristina Chimenti, Gianni Carola, Sanghamitra Mohanty, Chintan Trivedi, Mohamed Bassiouny, Amin Al-Ahmad, David J Burkhardt, Joseph G Gallinghouse, Javier E Sanchez, Rodney P Horton, Andrea Natale
Rok vydání: 2021
Předmět:
Zdroj: European Heart Journal Supplements. 23
ISSN: 1554-2815
1520-765X
DOI: 10.1093/eurheartj/suab134.053
Popis: Aims Left atrial appendage occlusion (LAAO) might be particularly attractive in chronic kidney disease (CKD) patients, owing to a high thromboembolic risk and an even higher risk of bleeding. We sought to evaluate the safety and effectiveness of LAAO in CKD patients. Methods and results A total of 1238 patients undergoing LAAO at six centres were enrolled. On the basis of kidney function, as assessed via the CKD-EPI formula, patients were classified in two groups. Group1 had a GFR value ≤60 ml/min/1.73 m2 (CKD stages 3a-b, 4, and 5), whereas Group2 had a function >60 ml/min/1.73 m2 (CKD stages 1 and 2). Predicted annual rates of TE or major bleeding events were compared to the annualized observed risk of the two populations. Compared to Group 2 (n = 720, 47.5% males), patients in Group 1 (n = 518, 86.5% males) were older (mean age: 78 ± 8 vs. 75 ± 8, P Conclusions LAAO is a safe and effective approach in CKD patients. Given the increased risk of bleeding and contraindications to oral anticoagulation, CKD patients might be good candidates for LAA occlusion.
Databáze: OpenAIRE
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