Combination chemotherapy in recurrent medulloblastoma
| Autor: | Michael E. Cohen, Lucius F. Sinks, Patricia K. Duffner, Arnold I. Freeman, Patrick R. M. Thomas |
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| Rok vydání: | 1979 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Vincristine Chemotherapy business.industry medicine.medical_treatment Combination chemotherapy Recurrent Medulloblastoma Asymptomatic Surgery Radiation therapy stomatognathic diseases Internal medicine medicine Methotrexate medicine.symptom business Dexamethasone medicine.drug |
| Zdroj: | Cancer. 43:41-45 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(197901)43:1<41::aid-cncr2820430105>3.0.co;2-u |
| Popis: | Five children with recurrent medulloblastomas were treated with Vincristine, BCNU, Methotrexate and Dexamethasone. All five patients responded to therapy. Two of the patients are alive and well 30 and 48 months later; one died of disease 19 months after first recurrence; one developed a further recurrence at 18 months but responded to additional chemotherapy and is alive; and the fifth patient developed a second recurrence after 28 months but has responded to repeat chemotherapy and radiotherapy and is now asymptomatic. These results support the concept that medulloblastomas are sensitive to chemotherapy and suggest that chemotherapy should be considered in cases of recurrent medulloblastomas. In addition, the importance of trials now in progress which employ both adjuvant chemotherapy and radiotherapy in newly diagnosed medulloblastomas is apparent. |
| Databáze: | OpenAIRE |
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