Crohnʼs Disease Activity
| Autor: | Solem E, Zielen S, Hans Georg Posselt, Bender Sw, Kreuz W, Scharrer I |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test business.industry C-reactive protein Gastroenterology Acute-phase protein Serum albumin Orosomucoid Inflammation Endocrinology Antigen Coagulation hemic and lymphatic diseases Internal medicine Erythrocyte sedimentation rate Pediatrics Perinatology and Child Health medicine biology.protein medicine.symptom business |
| Zdroj: | Journal of Pediatric Gastroenterology and Nutrition. 4:730-734 |
| ISSN: | 0277-2116 |
| DOI: | 10.1097/00005176-198510000-00008 |
| Popis: | Twenty-eight patients (mean age 13.5 years) with proven Crohn's disease were examined for factor VIII coagulation activity (VIII:C), factor VIII-related antigen (VIII R:Ag), and factor VIII-related ristocetin cofactor activity (VIII R:RCF). The factor VIII coagulation proteins were correlated with disease activity index according to van Hees and were compared with inflammatory parameters such as erythrocyte sedimentation rate, c-reactive protein, and orosomucoid. Among the factor VIII proteins, factor VIII-related protein (VIII R:Ag) correlates best with van Hees disease activity index, orosomucoid, c-reactive protein, and erythrocyte sedimentation rate (p less than 0.001 for all parameters). Since acute phase proteins are produced by liver cells, whereas VIII R:Ag is synthesized by endothelial cells, we postulate that this coagulation factor is highly sensitive in reflecting the inflammatory process in the intestine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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