Echinophora tenuifolia L. inflorescences: phytochemistry and in vitro antioxidant and anti-inflammatory properties in LPS-stimulated RAW 264.7 macrophages
| Autor: | Federica Menichini, Mariangela Marrelli, Giancarlo Statti, Filomena Conforti |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Traditional medicine
010405 organic chemistry Linoleic acid Plant Science 01 natural sciences Quercitrin 0104 chemical sciences Ferulic acid Palmitic acid 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Rutin Phytol chemistry Biochemistry Echinophora comic_books Carvacrol Ecology Evolution Behavior and Systematics comic_books.character |
| Zdroj: | Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology. 151:1073-1081 |
| ISSN: | 1724-5575 1126-3504 |
| DOI: | 10.1080/11263504.2016.1231142 |
| Popis: | During the last decades, different natural compounds have been demonstrated to modulate inflammatory pathways. In this study, methanolic extract of Echinophora tenuifolia L. inflorescences was investigated for its chemical composition and in vitro antioxidant and anti-inflammatory properties. Phytochemical profile was investigated by means of high-performance thin layer chromatography (HPTLC) and gas chromatography–mass spectrometry analyses. Myristic acid and palmitic acid were found to be the major constituents. Six terpenes were identified: α-phellandrene, o-cymene, dihydroactinidiolide, neophytadiene, phytol and β-amyrin, and two phenolic compounds: carvacrol and ferulic acid. HPTLC analysis of the ethyl acetate fraction highlighted the presence of the flavonoid glycosides rutin and quercitrin. This sample showed the best diphenylpicrylhydrazyl scavenging capacity, with an IC50 value equal to 40.39 μg/ml, and the strongest capacity to protect linoleic acid from peroxidation, as assessed by the... |
| Databáze: | OpenAIRE |
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