The influence of patient beliefs and treatment satisfaction on the discontinuation of current first-line antiretroviral regimens

Autor: Sara Bañón, Sacramento Moreno, A. C. Marin, José L. Casado, Miguel A Rodriguez-Sagrado, A. Moreno, M.J. Pérez-Elías, V Romero
Rok vydání: 2015
Předmět:
Zdroj: HIV Medicine. 17:46-55
ISSN: 1464-2662
DOI: 10.1111/hiv.12280
Popis: Objectives Large cohort studies have shown a high rate of first-line combination antiretroviral therapy (cART) regimen discontinuation in HIV-infected patients, attributed to characteristics of the cART regimen or toxicity. Methods A cohort study of 274 patients receiving a first-line regimen was carried out. Patients' perceptions and beliefs prior to initiation were assessed using an attitude towards medication scale (0−15 points), and their satisfaction during therapy was assessed using an HIV treatment satisfaction questionnaire (HIVTSQ). Treatment discontinuation was defined as any switch in the cART regimen. Results During 474.8 person-years of follow-up, 63 (23%) patients changed their cART regimen, mainly because of toxicity/intolerance (42; 67%). The overall rate of change was 13.2 per 100 patient-years [95% confidence interval (CI) 11.1–16.4 per 100 patient-years]. An efavirenz (EFV)-based single tablet regimen showed the highest rate of adverse events (27%), but the lowest rate of change (16%; 7.44 per 100 patient-years). Cox regression revealed a decreased hazard of first regimen termination with better initial attitude towards drugs [hazard ratio (HR) 0.76; 95% CI 0.62–0.93; P
Databáze: OpenAIRE
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