| Autor: |
Shigetada Teshima-Kondo, Kazuhito Rokutan, Ken Kurokawa, Kensei Nishida, Yuki Kuwano, Kiyoshi Masuda, Toshihito Tanahashi, Yuzuru Satake |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Gastroenterology. 138:S-257 |
| ISSN: |
0016-5085 |
| DOI: |
10.1016/s0016-5085(10)61173-0 |
| Popis: |
significantly. Lung apelin mRNA levels were unaffected. Exp 2: In Vitro hyperoxia reduced ileal cell apelin mRNA levels by 50% (P < 0.05). Exp 3: Overexpression of NF-κB reduced rat apelin core promoter activity by 60-80%. Mutation of putative NF-κB binding sites impaired NF-κB-induced reduction in apelin core promoter activity. Conclusions and Discussion. Our findings demonstrate that hyperoxia decreases intestinal apelin expression in the rat. NF-κB may play a role in the hyperoxia-induced reduction in intestinal apelin expression since NF-κB is activated by hyperoxia and overexpression of NF-κB downregulates apelin transcriptional activity. More importantly, these findings suggest that a reduced apelin expression may influence organogenesis in infants exposed to postnatal hyperoxia. It is well known that hypoxia upregulates apelin expression though HIF. This is the first demonstration of down-regulated apelin expression by hyperoxia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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