| Popis: |
Although a number of mediators (7) have been shown to mimic the protective effect of ischemia to precondition the heart, i.e., adenosine, acetylcholine, bradykinin, phorbol esters, and several end effectors or targets (7) of these substances have been identified, i.e., specific receptors, (Al, adenosine; M2 muscarinic; B2, bradykinin) ATP-sensitive potassium channels (KATP), protein kinase C (PKC), no strict criteria have been developed which are necessary to confirm that a substance or effector is an important component of the preconditioning response. This review is an attempt to develop such criteria and to summarize data which suggest that the KATP channel fits most of these criteria and meets the requirements necessary for it to qualify as a common pathway in the cardio protective effect produced by a variety of stimuli in different species or models. Infarct size reduction will be the end point used to define preconditioning since this parameter is the one which was used to originally demonstrate this fascinating phenomenon in canine hearts by Murry et al. (6). |
