Alkylation of CH-Acids with 3-Halomethyl Derivatives of Ethyl (Diethoxyphosphorylmethyl)furoates

Autor:	A. I. Ponyaev, V. S. Zavgorodnii, L. M. Pevzner
Rok vydání:	2020
Předmět:	Chloroform 010405 organic chemistry Acetylacetone Hydrazine General Chemistry Alkylation 010402 general chemistry 01 natural sciences Medicinal chemistry Enol 0104 chemical sciences chemistry.chemical_compound chemistry Furan Methylene Hydrate
Zdroj:	Russian Journal of General Chemistry. 90:2068-2079
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363220110092
Popis:	Alkylation at the carbon atom of the active methylene group of 3-halomethyl derivatives of phosphonocarboxylic acid esters of the furan series with acetylacetone, acetoacetic, malonic and cyanoacetic esters in an absolute ethanol–dioxane medium (1 : 10) in the presence of sodium ethylate leads to the formation of the corresponding monoalkyl derivatives. The obtained phosphonomethylated derivatives of 3-(furylmethyl)acetylacetone and ethyl 2-(furylmethyl)acetoacetate react with hydrazine hydrate to form phosphorus-containing derivatives of (furyl)(pyrazolyl)methanes and (furyl)(pyrazolonyl)methanes, respectively. The latter in chloroform exist exclusively in enol form.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::74856bd351dfbb074bf11e6fef532bc2 https://doi.org/10.1134/s1070363220110092 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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