| Popis: |
Background: Serum anti-glycan antibodies are a promising tool for differential diagnosis, disease stratification and prediction of Crohn's disease (CD). We assessed the presence of serum anti-glycan antibodies in affected and non-affected relatives of patients with CD and ulcerative colitis (UC). Methods: 393 non-inflammatory bowel disease (IBD)-affected relatives (330 CD and 63 UC relatives) of 169 IBD patients (140 CD and 29 UC patients) as well as 46 healthy controls were tested for the presence of anti-laminarin IgA (Anti-L), anti-chitin IgA (Anti-C), anti-chitobioside IgA (ACCA), anti-laminaribioside IgG (ALCA), anti-mannobioside IgG (AMCA) and anti-Saccaromyces cervisiae IgG (gASCA) carbohydrate antibodies by ELISA in a blinded fashion. Detailed clinical data of the IBD patients were available. Results:Non-affected relatives of CD patients had lower antibody levels for gASCA, ALCA, Anti-L and Anti-C and a lower quartile sum score (QSS), compared to the affected CD subjects (p |
