Karakteristik Histopatologik dan Imunofenotipik Kanker Payudara di Rumah Sakit Cipto Mangunkusumo Jakarta, Indonesia

Autor:	Stephanie Marisca, Primariadewi Rustamadji
Rok vydání:	2018
Předmět:	medicine.medical_specialty business.industry General Engineering Anatomical pathology Luminal a Luminal b medicine.disease Gastroenterology Genetic profile Breast cancer Immunophenotyping Internal medicine Tumor stage medicine Immunohistochemistry skin and connective tissue diseases business
Zdroj:	Medicinus. 6
ISSN:	2622-6995 1978-3094
DOI:	10.19166/med.v6i3.1147
Popis:	Introduction: Breast cancer can be classified into luminal A, luminal B, Her2+, dan basal-like molecular subtype according to genetic profile and immunophenotype. The aim of this study is to assess histopathologic and immunophenotype characteristics of breast cancer in Cipto Mangunkusumo Hospital Jakarta, Indonesia.Material and methods: This study is a cross-sectional retrospective study. The sample was 2632 breast cancer case in Department of Anatomical Pathology Cipto Mangunkusumo Hospital from the year 2011 until 2015. ER, PR, Her2, Top2 α, and Ki67 immunohistochemical stain was then grouped into luminal A (ER+/PR+/Her2-/Ki67Result: The most prevalent to the less prevalent breast cancer molecular subtype was luminal B (43,9%), Her2+ (14,6%), luminal A (14,0%), and basal-like (11,3%). There was a significant association between the tumor stage and breast cancer subtype (p=0,0001). There is also a significant association between Top2α expression and molecular subtype (p=0,0001).Conclusion: The most prevalent breast cancer molecular subtype was luminal B. There was an association between breast cancer molecular subtype and a higher degree and Top2α expression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::74710b2cde08a8bdfc328edb1961e21a https://doi.org/10.19166/med.v6i3.1147 Zobrazit plný text záznamu