Additional file 3: Figure S3. of Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

Autor: Peck, Barrie, Schug, Zachary, Qifeng Zhang, Dankworth, Beatrice, Jones, Dylan, Smethurst, Elizabeth, Rachana Patel, Mason, Susan, Jiang, Ming, Saunders, Rebecca, Howell, Michael, Mitter, Richard, Spencer-Dene, Bradley, Stamp, Gordon, McGarry, Lynn, James, Daniel, Shanks, Emma, Aboagye, Eric, Critchlow, Susan, Hing Leung, Harris, Adrian, Wakelam, Michael, Gottlieb, Eyal, Schulze, Almut
Rok vydání: 2016
Předmět:
DOI: 10.6084/m9.figshare.c.3600182_d10
Popis: Spectrum of free fatty acids of DU145 cells after SCD inhibition. DU145 cells were treated with SCD inhibitors (100nM) or solvent (DMSO) for 48hrs in medium with low serum or supplemented with BSA or BSA-coupled oleic acid (BSA-oleate). (a) Amounts of different FFA species. (b) Amounts of selected saturated and mono-unsaturated FFAs. (c) Relative contribution of FFA species to total FFA pool. (d) Relative contribution of selected saturated and mono-unsaturated FFA species to total FFA pool. Data represent mean ÂąSEM of three independent biological replicates. Statistical comparisons were performed using Student t-test (*pâ ¤0.05). (PDF 648 kb)
Databáze: OpenAIRE