Radiation therapy for early stage Hodgkin's disease: Australasian patterns of care
| Autor: | George Quong, David Joseph, Kuen H. Liew, Quenten Walker, John Boyages, Margaret Wallington, Graeme Morgan, Sidney Davis, G. Trotter, Elizabeth Crennan, Michael Barton, Richard Fisher, Gary Pratt, Susan Pendlebury, Peter C. O'Brien, Deborah Thornton, Neva Johnson, Carolyn Hook |
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| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
medicine.medical_specialty Radiation Lung business.industry medicine.medical_treatment Thyroid Disease medicine.disease Surgery Lymphoma Radiation therapy medicine.anatomical_structure Oncology medicine Radiology Nuclear Medicine and imaging Stage (cooking) business Complication Survival analysis |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 31:227-236 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/0360-3016(94)e0261-h |
| Popis: | Purpose: Analysis of treatment outcome for Stage I-IIA supradiaphragmatic Hodgkin's disease treated solely by irradiation in Australia and New Zealand. Methods and Materials: Patients with supradiaphragmatic Hodgkin's disease only who were treated by irradiation alone with curative intent between 1969 to 1988 were retrospectively reviewed. Ten radiation oncology departments in Australia and New Zealand contributed patient data to the study. Patient, tumor, and treatment variables were recorded. Disease-free interval, survival, and complications were analyzed. Results: Eight hundred and twenty patients were reviewed. The median age was 29 years. There were 437 men and 383 women. The distribution of 310 clinically staged patients was 170 stage IA, 5 IB, and 135 IIA. Five hundred and ten patients received laparotomies, and pathologic staging was as follows: IA 214, IB 13, IIA 283. The 10-year actuarial disease-free rate was 69% and overall survival rate was 79%. Increasing age, male sex, higher number of involved sites, the use of involved field irradiation, no staging laparotomy, and earlier year of treatment were significantly associated with an increased risk of relapse and lower survival. Actuarial 10-year survival following recurrence was 48%. Acute complications requiring interruption to treatment occurred in 46 patients (6%), but |
| Databáze: | OpenAIRE |
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