Comparison of three tumor markers—CA-125, lipid-associated sialic acid (LSA), and —In monitoring ovarian cancer
| Autor: | E. Petru, Susan G. Hilsenbeck, James P. Perras, Ossi R. Koechli, Hervy E. Averette, B.U. Sevin |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Disease status business.industry Obstetrics and Gynecology Cancer Ovary medicine.disease Gastroenterology Sialic acid chemistry.chemical_compound medicine.anatomical_structure Endocrinology Oncology chemistry Internal medicine medicine Lipid-associated sialic acid Epithelial ovarian cancer In patient Ovarian cancer business |
| Zdroj: | Gynecologic Oncology. 38:181-186 |
| ISSN: | 0090-8258 |
| Popis: | The monitoring value of three tumor markers—CA-125, lipid-associated sialic acid (LSA), and NB70K—alone and in combination has been studied in 152 patients with invasive, epithelial ovarian cancer. The sensitivity and specificity of CA-125 (90 and 92%, respectively) were superior to those of LSA (79 and 63%, respectively) and NB70K (76 and 74%, respectively). CA-125 by itself showed equal or higher sensitivity as well as higher specificity than in combinations with either LSA or NB70K. CA-125 predicted cancer at second-look in 87% of cases as did LSA and NB70K in 70 and 57%, respectively. In patients with negative second-look, CA-125 predicted the disease status in 93% as did LSA and NB70K in 54 and 63%, respectively. On the basis of these data, the value of simultaneous determination of LSA and NB70K, in addition to the clinically established CA-125, seems to be limited. This is due mainly to the lack of specificity of LSA and NB70K. However, the sensitivity and specificity of CA-125 in this study were in the upper reported range. |
| Databáze: | OpenAIRE |
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