Chemical constituents from the aerial parts of Psammosilene tunicoides

Autor:	Wei-Dong Zhang, Lei Shan, Bing-Yang Chen, Bo Wen, Xin Yuan, Bo Li, Ka-Li Fu, Yun-Heng Shen, Ji Ye
Rok vydání:	2014
Předmět:	HCT116 Cell chemistry.chemical_classification Ethanol Stereochemistry Chemistry Glycoside Plant Science Biochemistry chemistry.chemical_compound Psammosilene tunicoides Cell culture Chemical constituents Organic chemistry No production Cytotoxicity Agronomy and Crop Science Biotechnology
Zdroj:	Phytochemistry Letters. 9:59-66
ISSN:	1874-3900
DOI:	10.1016/j.phytol.2014.04.006
Popis:	Investigation of the 80% ethanol extract of the aerial parts of Psammosilene tunicoide afforded two carboline alkaloids (1–2), a γ-pyrone derivative (3), two p-hydroxy cinamic acid derivatives (4–5), two glycosides (6–7) and six known compounds (8–13). Their structures were established on the basis of spectroscopic analysis (1D-, 2D-NMR, ESI-MS, and HR-ESI-MS). All these compounds were evaluated for cytotoxicity against SMML-7721, A549, HCT116, and MCF-7 cell lines, and for inhibitory activity against NO production in LPS-induced RAW264.7 macrophages. However, only compound 2 had weak cytotoxic activity against the HCT116 cell line at 20 μM, while the others are inactive against four human tumor cell lines and only show weak inhibition activity against NO production at 50 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::745dbc65a2069d28255fefda7f3195d4 https://doi.org/10.1016/j.phytol.2014.04.006 Zobrazit plný text záznamu Full Text from ScienceDirect