Abstract 091: Leptin-Thyroliberin Pathway in Left Ventricle Hypertrophy

Autor:	Mariano Luis Schuman, Jorge E. Toblli, Maria Silvina Landa, Silvia I. García, Ludmila Soledad Peres Diaz, Maia Aisicovich
Rok vydání:	2019
Předmět:	medicine.medical_specialty Left ventricle hypertrophy Adiponectin business.industry Leptin digestive oral and skin physiology 030204 cardiovascular system & hematology medicine.disease Obesity Muscle hypertrophy 03 medical and health sciences 0302 clinical medicine Endocrinology Fibrosis Internal medicine Internal Medicine medicine 030212 general & internal medicine business hormones hormone substitutes and hormone antagonists
Zdroj:	Hypertension. 74
ISSN:	1524-4563 0194-911X
Popis:	Cardiac TRH (cTRH) induces LVH and fibrosis. The adiponectin Leptin induces TRH in CNS. We hypothesized that in obesity, the increase of cTRH induced by hyperleptinemia is responsible for the LVH, mostly attributed to pressure load. We studied obese hyperleptinemic with mild hypertension Agouti mice, and found LVH with higher (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::74584501bfaad8d4bfd4286b1edbea1d https://doi.org/10.1161/hyp.74.suppl_1.091 Zobrazit plný text záznamu