Ni-catalyzed α-arylation of secondary α-bromo-α-fluoro-β-lactam: cross-coupling of a secondary fluorine-containing electrophile

Autor:	Hideki Minami, Yoshihisa Miwa, Shoji Kondo, Atsushi Tarui, Kazuyuki Sato, Akira Ando, Masaaki Omote
Rok vydání:	2013
Předmět:	Chemistry Aryl Organic Chemistry chemistry.chemical_element Fluorine containing Oxazoline biochemical phenomena metabolism and nutrition Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound Reagent Drug Discovery Electrophile polycyclic compounds Fluorine Lactam
Zdroj:	Tetrahedron. 69:1559-1565
ISSN:	0040-4020
DOI:	10.1016/j.tet.2012.12.002
Popis:	A highly diastereoselective cross-coupling reaction of an α-bromo-α-fluoro-β-lactam with a wide range of aryl Grignard reagents was catalyzed by Ni/bis(oxazoline) in yields of up to 98%. The product was obtained diastereoselectively as an anti-isomer. This is the first successful α-arylation of an α-fluoro-β-lactam to produce diverse α-aryl-α-fluoro-β-lactams.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::744cc13050a6bcec48939ddca152c55e https://doi.org/10.1016/j.tet.2012.12.002 Zobrazit plný text záznamu Full Text from ScienceDirect