Amino Acid Organotin Polymers from Diglycine-Synthesis, Structural Characterization and Initial Anticancer Activity
| Autor: | Lindsey Miller, Charles E. Carraher, Alisa Moric-Johnson, Paul Slawek, Jerome E. Haky, Michael R. Roner, Francesca Mosca |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Dipeptide Polymers and Plastics Infrared spectroscopy 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences Amino acid chemistry.chemical_compound chemistry Diglycine Yield (chemistry) Materials Chemistry Amine gas treating 0210 nano-technology Alkyl |
| Zdroj: | Journal of Inorganic and Organometallic Polymers and Materials. 30:182-195 |
| ISSN: | 1574-1451 1574-1443 |
| DOI: | 10.1007/s10904-019-01222-z |
| Popis: | Poly(amine esters) were synthesized from reaction of organotin dichlorides with the dipeptide diglycine. The products were generally high polymers and produced in high yield with yield increasing as the organotin alkyl chain increases in length. Reaction is rapid. Bands characteristic of the formation of the Sn–O–(C=O) and Sn–NH are found in the infrared spectra of the product. MALDI MS and NMR results are consistent with the proposed structure. The products show decent inhibition of all of the tested human solid cancer cell lines including two human pancreatic, two human breast and two human brain cancer cell lines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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