The Frequency of UGT2B7*2 (802C>T) Allele among Healthy Unrelated Jordanian Volunteers
Autor: | Abdel Qader Al-Bawab, Yazun Jarrar, Obaid A, Kherfan F, Lama Hamadneh |
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Rok vydání: | 2016 |
Předmět: |
Genetics
business.industry Heterozygote advantage Bioinformatics 030226 pharmacology & pharmacy Confidence interval UGT2B7 law.invention Genotype frequency 03 medical and health sciences 0302 clinical medicine law 030220 oncology & carcinogenesis Genotype Medicine Allele Restriction fragment length polymorphism business Polymerase chain reaction |
Zdroj: | Journal of Drug Metabolism & Toxicology. |
ISSN: | 2157-7609 |
Popis: | The UDP-Glucuronesyl Transferase (UGT) 2B7*2 802C>T is the most common functional genetic variant on UGT2B7 gene with reported influence on drug response. Objective: To determine the frequency of UGT2B7*2 (802C>T) genetic variant among Jordanian population. Methods: The DNA samples from 90 healthy Jordanian volunteers were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism assays (PCR-RFLP) to determine the UGT2B7*2 allele. Results: The frequency (95% confidence interval) of UGT2B7*2 802C allele was 0.59 (0.52 to 0.66) and for UGT2B7*2 802T was 0.41 (0.34 to 0.48), which was similar to the Caucasian but different than African ethnic populations. The UGT2B7 genotype frequency among Jordanians was 0.31 (0.22 to 0.4) for wild, 0.57(0.47 to 0.67) for heterozygote and 0.12 (0.06 to 0.18) for homozygote UGT2B7*2 genotype. Conclusion: This study reported for the first time the UGT2B7*2 frequency and genotype profile among Jordanians. The findings of this study will increase our understanding in explaining the inter-individual variation in drug response among Jordanian population. |
Databáze: | OpenAIRE |
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