| Autor: |
Patrick Fier, Kevin Maloney, Grant Murphy, Neil Strotman, William Morris, Jessica Hurtak, Anders Knight, Jonathan Vroom, Hsing-I Ho, Weilan Pan, Deeptak Verma, Mark Huffman, Hao Yang, Tetsuji Itoh, Peter Maligres, Jongrock Kong, Steven Silverman, John McIntosh, Tamas Benkovics |
| Rok vydání: |
2020 |
| Popis: |
Molnupiravir (MK-4482) is an investigational direct-acting antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand for this compound, it was critical to develop a sustainable and efficient synthesis from commodity raw materials. The three-step route that we report here embodies the shortest possible synthesis to molnupiravir, and was enabled through the invention of a novel biocatalytic cascade and final condensation step. Each step occurs in over 95% yield and only utilizes widely available commodity reagents and simple operations. Compared to the initial route, the new route is 70% shorter, and approximately seven-fold higher in overall yield. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
