ChemInform Abstract: Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by o-Xylylene-Type Chiral 1,4-Amino Alcohols with an Aminal Structure

Autor:	Masatoshi Asami, Suguru Ito, Yoshitaka Yamaguchi, Ayano Hasome, Naoyuki Yachi, Naoya Hosoda
Rok vydání:	2016
Předmět:	chemistry.chemical_compound chemistry Aminal Enantioselective synthesis Organic chemistry General Medicine Diaryl ketone Xylylene Diethylzinc Pyrrolidine Catalysis
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201633027
Popis:	A series of o-xylylene-type chiral 1,4-amino alcohols with an aminal structure was synthesized starting from (S)-2-(arylaminomethyl)pyrrolidine, o-bromobenzaldehyde, and a diaryl ketone. The enantioselective addition of diethylzinc to aldehydes was examined by using the 1,4-amino alcohols, and the corresponding chiral secondary alcohols were obtained with high enantioselectivities (up to 98% ee).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::743f62dff210b25548efdb7c162fe2e6 https://doi.org/10.1002/chin.201633027 Zobrazit plný text záznamu Plný text