Identification of isobutyl angelate, isoamyl angelate and 2-methylbutyl isobutyrate as active constituents in Roman chamomile essential oil that promotes mouse ambulation
| Autor: | Junko Hayashi, Tomoharu Sano, Toyoshi Umezu, Yasuyuki Shibata, Yasuko Yoshikawa |
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| Rok vydání: | 2017 |
| Předmět: |
Traditional medicine
biology Chemistry education Chamaemelum Ms analysis General Chemistry Cns effects biology.organism_classification law.invention 03 medical and health sciences Ingredient 0302 clinical medicine Mental condition Biochemistry law 030220 oncology & carcinogenesis parasitic diseases Roman Chamomile Anthemis 030217 neurology & neurosurgery Essential oil Food Science |
| Zdroj: | Flavour and Fragrance Journal. 32:433-439 |
| ISSN: | 0882-5734 |
| DOI: | 10.1002/ffj.3397 |
| Popis: | Roman chamomile (Chamaemelum nobile or Anthemis nobilis) has traditionally been used for health care, health maintenance and medicinal purposes, and the essential oil obtained from the flowers is used as a basic ingredient for aromatherapy. Roman chamomile essential oil (CHA) produces psychostimulant-like effects, such as the ambulation-promoting effect, on mouse behaviour. However, mechanisms underlying the effects of CHA remain unclear. The present study aimed to identify the constituents responsible for the ambulation-promoting effect of CHA and to elucidate a possible neuronal mechanism. GC/MS analysis revealed that isobutyl angelate, isoamyl angelate and 2-methylbutyl isobutyrate were the major constituents of CHA. These compounds significantly promoted mouse ambulation, and were thus identified as the major active constituents for the ambulatory effect of CHA. The ambulatory effects were attenuated by chlorpromazine and haloperidol, suggesting that the neurotransmitter dopamine is involved in the ambulation-promoting effects of these constituents similar to already-known psychostimulants. The results suggest that CHA can change a mental condition, at least in part, through the CNS effects of the constituents identified in the current study. The results also suggest that mental effects of CHA are largely different from those of other Roman chamomile preparations due to the composition difference. |
| Databáze: | OpenAIRE |
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