The Phosphodiester Groups of d(TpT)− and d(TpG)- Coordinate to Platinum(II) in N,N-Dimethylformamide

Autor:	Gilles Barre, Jiří Kozelka
Rok vydání:	1997
Předmět:	inorganic chemicals Denticity Guanine Stereochemistry Organic Chemistry food and beverages chemistry.chemical_element General Chemistry Nuclear magnetic resonance spectroscopy Catalysis Adduct chemistry.chemical_compound chemistry Phosphodiester bond Atom Platinum DNA
Zdroj:	Chemistry - A European Journal. 3:1405-1409
ISSN:	1521-3765 0947-6539
DOI:	10.1002/chem.19970030906
Popis:	The propensity of the phospho-diester group to bind platinum(II) was investigated by examining the reactions of the dinucleotide salts NH4{d(TpT)} and NH4{d(TpG)} with the complexes [Pt-(NO3)(NH3)3]NO3 (1) and cis-[Pt(NO3)2-(NH3)2] (2) in N,N-dimethylformamide. d(TpT)- coordinates to the platinum atom of both 1 and 2 through either of the two nonbridging phosphoryl oxygen atoms, as revealed by 31P NMR spectroscopy. Conversely, d(TpG)- binds to 1 through the guanine N7 atom. With 2, d(TpG)- forms monodentate adducts bound to N7(G), as well as two distinct macrochelates, in which N7(G) and one of the nonbridging phosphoryl oxygens are crosslinked by platinum. We suggest that guanine-phosphoryl macrochelate complexes play a role as intermediates in rearrangements of platinum monoadducts formed with DNA.
Databáze:	OpenAIRE
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