Producing the cortical phenomenon of 'kindling' during acute experiments on cats

Autor: E. G. Zolotilina, V. G. Goff, V. M. Okudzhava
Rok vydání: 1986
Předmět:
Zdroj: Neurophysiology. 17:429-433
ISSN: 1573-9007
0090-2977
DOI: 10.1007/bf01052176
Popis: Acute experiments on cats enabled spontaneous epileptogenic foci to be produced by means of electrical stimulation of the cerebral cortex. The central area of the suprasylvian gyrus was stimulated by 5-sec stimuli at 3-sec intervals. The strength of neuronal response gradually increased until spontaneous electrical activity set in as stimulation was set at a fixed intensity which had originally evoked local residual discharge at stimulation foci only, i.e., the phenomenon of "kindling" was observed. When "kindling" was produced in the cortical area under study, bursts of spindle activity were recorded on all ECoG with increasing frequency. Recordings of spindle activity then changed to a "spike-wave" pattern of activity. The results of these investigations, which were performed on an isolated strip of cortex, point to the involvement of subcortical structures in mediating "kindling" of the cortical focus.
Databáze: OpenAIRE
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