Does the Emperor Have Any Clothes: Using Mechanistic Information or Doing Houdini Risk Assessments?
| Autor: | Franklin E. Mirer |
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| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Human and Ecological Risk Assessment: An International Journal. 8:1229-1242 |
| ISSN: | 1549-7860 1080-7039 |
| Popis: | Risk assessment research rarely quells controversy. Mega-mouse, and mega-rat, experiments contradicted a threshold for carcinogenesis, yet thresholds are still argued. High to low dose continuity of response from cigarette smoking to environmental tobacco smoke, and from occupational asbestos exposure to take-home asbestos, contradict thresholds in people. Nevertheless, mechanistic hypotheses allege “Houdini Risk Assessments”, which make risks disappear or allow industries to escape from protecting workers. Despite concerns for animal-to-human extrapolations, priority occupational exposures with sufficient or substantial evidence of carcinogenicity in people not addressed by new exposure limits include silica, sulfuric acid mist, chromates, diesel particulate matter, particulate matter generally, metalworking fluids, welding fume, and formaldehyde. “Houdini Risk Assessments” are exercises in “anti-hypothesis generation”: ignore selected tumor sites and types; ignore data from people (as with formaldehyde ... |
| Databáze: | OpenAIRE |
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