Evaluation of the Long-Term Action of Cinnarizine Nanoparticles Based on Poly(D,L-Lactide-Co-Glycolide)

Autor:	L. I. Shcherbakova, D. I. Pozdnyakov, N. S. Zyablitseva, M. V. Sorokoumova, D. V. Kompantsev, E. G. Sannikova, V. A. Kompantsev, Kirill A Miroshnichenko
Rok vydání:	2021
Předmět:	Pharmacology Drug Cinnarizine media_common.quotation_subject Nanoparticle Reference drug Dosage form PLGA chemistry.chemical_compound Cerebral blood flow chemistry Drug Discovery medicine Poly d l lactide media_common medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 55:706-710
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-021-02481-2
Popis:	The long-term pharmacological action of cinnarizine nanoparticles based on biodegradable poly(D,L-lactide-co-glycolide) (PLGA) was studied using adult male Wistar rats (240 – 260 g). The reference drug was cinnarizine substance at a dose of 5.6 mg/kg. Changes in the cerebral hemodynamics were studied by ultrasound dopplerography, measured as the level of cerebral blood flow recorded over time intervals of 2, 4, 6, 8, 10, and 12 h and characterized by indicators of systolic linear and volumetric velocities of cerebral hemodynamics in terms of the Pourcelot and Gosling indices. The study revealed prolongation of the cinnarizine effect for 12 h, which favorably distinguished the developed PLGA dosage form from other drugs available on the pharmaceutical market, which is likely to mitigate side effects of the parent drug.
Databáze:	OpenAIRE
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