Facile installation of the phosphonate and (α,α-difluoromethyl)phosphonate functionalities equipped with benzyl protection

Autor:	Gorka Peris, David B. Berkowitz, Debnath Bhuniya
Rok vydání:	1999
Předmět:	chemistry.chemical_compound Primary (chemistry) Hydrogenolysis Chemistry Organic Chemistry Drug Discovery Organic chemistry Biochemistry Phosphonate
Zdroj:	Tetrahedron Letters. 40:1869-1872
ISSN:	0040-4039
Popis:	Under appropriate conditions, dibenzyl (lithiomethyl)phosphonate and dibenzyl (lithiodifluoromethyl)phosphonate displace primary triflates to provide convenient access to the corresponding phosphonates, carrying benzyl ester protecting groups. This approach is of particular advantage for phosphonate ester deprotection, which may be achieved by simple hydrogenolysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7423e877d738efc0ddf1372313417415 https://doi.org/10.1016/s0040-4039(99)00077-5 Zobrazit plný text záznamu Full Text from ScienceDirect