| Popis: |
Background: Vitamin D (25(OH)D) is a fat-soluble secosteroid hormone that plays a major role in bone mineralization and other metabolic processes in the human body. A complex between biologically active vitamin D (1,25(OH)2D) and its receptor serves as a transcription factor for various genes involves in bone homeostasis. Several studies have been link vitamin D deficiency with a reduction in Bone Mineral Density (BMD), but the result was still conflicting. However, data regarding vitamin D deficiency in the Indonesian population are rarely available.Objective: The study aims to assess vitamin D status and its correlation with Bone Mineral Density (BMD) among Javanese elderly women.Methods: A cross-sectional study was conducted in 75 healthy Javanese elderly women aged 60-84 years old. Serum Vitamin D was measured by enzyme link immunoassay using 25(OH)D ELISA kit. BMD was measured by dual-energy X-ray absorptiometry (DXA).Results: Mean±SD serum 25(OH)D level of the study population was 14.97±6.6ng/mL, we found that 73.3% were vitamin D deficient and 26.7% did not. There is no correlation between vitamin D and BMD lumbar, femoral neck or T-score (p=0.064, -0.215; p=0.443, -0.090; and p=0.109, -0.187 respectively). Lower BMD lumbar, femoral neck and T-score was correlated with increased age (r=-0.238, p=0.040; r=-0.377, p=0.001; and r=-0.295, p=0.010 respectively) and decreased BMI (r=0.525, p=0.000; r=0.516, p=0.000; and r=0.520, p=0.000 respectively).Conclusion: From this study, we concluded that vitamin D deficiency was prevalent among Javanese elderly women. However, there is no correlation has been found between vitamin D status and bone mineral density in this population. |
