Pre-Clinical Safety Evaluation of Pyrrolidine Dithiocarbamate
| Autor: | Otto Doblhoff-Dier, Thomas Muster, Monika Chabicovsky, Oliver H. J. Szolar, Joachim Seipelt, Alexandra Hebar, Eva Prieschl-Grassauer |
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| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
Drug business.industry media_common.quotation_subject General Medicine Toxicology medicine.disease_cause chemistry.chemical_compound Dose–response relationship Pyrrolidine dithiocarbamate chemistry Pharmacokinetics Toxicity Medicine Clinical safety Nasal administration Rhinovirus business media_common |
| Zdroj: | Basic & Clinical Pharmacology & Toxicology. 107:758-767 |
| ISSN: | 1742-7835 |
| DOI: | 10.1111/j.1742-7843.2010.00573.x |
| Popis: | Pyrrolidine dithiocarbamate (PDTC) was examined for its potential in the intranasal treatment of human rhinovirus infections. Prior to clinical testing, a comprehensive non-clinical programme was performed to evaluate the general toxicity of PDTC. The animal experiments included investigations in rodents with study durations ranging from single dose to repeated dosing over a period of 28 days. The routes of administration were intranasal, inhalative, oral and intravenous for single-dose toxicity and pharmacokinetic studies, and intranasal for repeated dose studies. Blood and tissue samples were obtained from PDTC-treated rats to analyse pharmacokinetics and tissue distribution. Accumulation of selected metals due to PDTC treatment was examined in liver, brain, nerves and fat tissues. |
| Databáze: | OpenAIRE |
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