Autor:	M. V. Rapallino, Holger Hydén, Aroldo Cupello
Rok vydání:	1999
Předmět:	GABAA receptor Chemistry Ionic bonding Cell Biology General Medicine Permeation Chloride Cellular and Molecular Neuroscience Membrane Energy profile Biochemistry Chloride channel medicine Biophysics Ion channel medicine.drug
Zdroj:	Cellular and Molecular Neurobiology. 19:681-690
ISSN:	0272-4340
DOI:	10.1023/a:1006944820946
Popis:	1.Data obtained studying permeability characteristics of single Deiters' membranes in a microchamber system show that intracellular GABA can activate chloride in → out passage with a GABAA pharmacology. 2.The overall data suggest the presence of a chloride extrusion pump in these neurons based on intracellular GABA activated chloride channels. 3.This conclusion takes up a previous theoretical suggestion that ionic channels could work as ionic pumps provided an energy input modifies the energy profile along the permeation path. 4.According to our quantitative evaluation, this pumping mechanism works with a low yield and along a cycle with a strongly asymmetric behavior, being far from equilibrium due to powerful “leakage” pathways for chloride in these neurons.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7412423553b0de4d6f11c45480a8ae84 https://doi.org/10.1023/a:1006944820946 Zobrazit plný text záznamu Full text from SpringerLink