Midgut Neuroendocrine Tumors with Liver-only Metastases: Benefit of Primary Tumor Resection
| Autor: | Jun Gong, Andrew Eugene Hendifar, Jessica S. Crystal, Nicholas Manguso, Alexandra Gangi, Richard Tuli, Shirley C Paski |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Cancer Retrospective cohort study 030230 surgery Neuroendocrine tumors medicine.disease Gastroenterology Primary tumor 03 medical and health sciences 0302 clinical medicine Oncology Surgical oncology 030220 oncology & carcinogenesis Internal medicine medicine T-stage Surgery Stage (cooking) business Survival rate |
| Zdroj: | Annals of Surgical Oncology. 27:4525-4532 |
| ISSN: | 1534-4681 1068-9265 |
| Popis: | Management of metastatic midgut neuroendocrine tumors (MNET) remains controversial. The benefits of resecting the primary tumor are not clear and advocated only for select patients. This study aimed to determine whether resection of the primary MNET in patients with untreated liver-only metastases has an impact on survival. This retrospective study reviewed data of the National Cancer Database from 2004 to 2015 for patients with liver-only metastatic MNETs and compared those who received resection of their primary MNET with those who did not. Patient demographics, tumor characteristics, and clinical outcomes were compared between the groups. The primary outcome was overall survival (OS) after adjustment for patient, demographic, and tumor-related factors. The study identified 1952 patients with a median age of 63 years (range, 18–90 years). The median primary tumor size was 2.4 cm (range, 0.1–20 cm). Of these patients, 1295 (66%) underwent resection of the primary tumor and 667 (34%) did not. The patients who underwent resection were younger (median age, 63 vs 65 years; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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