Bedeutung der Hypoxiebildgebung mit PET für die Bestrahlungsplanung

Autor:	F. Paulsen, S. M. Eschmann
Rok vydání:	2008
Předmět:	Prognostic factor PET-CT Tumor hypoxia business.industry medicine.medical_treatment Vessel occlusion Hypoxia (medical) Radiation therapy medicine Intensity modulated radiotherapy medicine.symptom Nuclear medicine business Radiation treatment planning
Zdroj:	Der Nuklearmediziner. 31:33-36
ISSN:	1439-5800 0723-7065
DOI:	10.1055/s-2008-1004618
Popis:	Tumor hypoxia is an important prognostic factor for radiotherapy of various malignant tumors. Several promising PET tracers for non-invasive imaging of tumor hypoxia have been developed in the past years which were meant to replace invasive measurements by pO 2 -histography. However, none of these tracers has been introduced into clinical routine radiotherapy planning though throughout the literature the potential of these tracers for imaging of hypoxia could be proven. One reason for this lack of acceptance of hypoxia PET may be the non-optimal tumor-to background-relation which makes tumor delineation and integration of PET information into treatment planning difficult. Furthermore, the meaning of different phases of hypoxia (acute vessel occlusion or chronic diffusion distance), their measurement and integration into radiotherapy remain unknown. New methods for integration of differentiately acquired PET information into intensity modulated radiotherapy planning (IMRT) have been developed meanwhile.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::740bb082f4198ed1daa7ffce567b51ae https://doi.org/10.1055/s-2008-1004618 Zobrazit plný text záznamu