| Autor: |
Victoria K. Baxter, Elizabeth J. Anderson, Sharon A. Taft-Benz, Kelly Olsen, Maria Sambade, Kaylee M. Gentry, Wolfgang Beck, Jason Garness, Allison Woods, Misha Fini, Brandon Carpenter, Christof C. Smith, Mark T. Heise, Benjamin Vincent, Alex Rubinsteyn |
| Rok vydání: |
2022 |
| Popis: |
There is significant interest in T-cell mediated immunity against SARS-CoV-2. Both vaccination and infection have been observed to elicit durable T-cell responses against the virus. The classical role of CD4+ T-cell responses in coordinating humoral immunity is well understood but it is less clear to what degree, if any, T-cell responses play a direct protective role against infection In this study we vaccinated BALB/c mice with peptides derived from the SARS-CoV-2 proteome designed to either elicit T-cell responses or B-cell responses against linear epitopes. These peptides were administered in combination with either of two adjuvants, poly(I:C) and the STING agonist BI-1387466. Both adjuvants consistently elicited responses against the same peptides, preferentially from the group selected for predicted T-cell immunogenicity. The magnitude of T-cell responses was, however, significantly higher with BI-1387466 compared with poly(I:C). Neither adjuvant group, however, provided any protection against infection with the murine adapted virus SARS-CoV-2-MA10 or from disease following infection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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