EFFECT OF MURRAYA KOENIGII LEAVES EXTRACT ON GLUCONEOGENESIS AND GLYCOGENOLYSIS IN ISOLATED RAT HEPATOCYTES CULTURE

Autor:	Pratik P. Durgawale, Kailas D. Datkhile, Chitra C. Khanwelkar, Rohan Sharadanand Phatak
Rok vydání:	2018
Předmět:	Pharmacology Glycogenolysis Murraya biology Glycogen Pharmaceutical Science Carbohydrate biology.organism_classification In vitro chemistry.chemical_compound medicine.anatomical_structure Gluconeogenesis chemistry Hepatocyte medicine Pharmacology (medical) Ex vivo
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. 11:264
ISSN:	2455-3891 0974-2441
Popis:	Objectives: The present study was aimed to investigate the in vitro activity of Murraya koenigii extracts through various carbohydrate metabolic pathways in the isolated rat hepatocyte models.Methods: Different doses of metformin, aqueous and methanol extracts of M. koenigii leaves were evaluated in the MTT, glucose, and glycogen content assays in the cultured in vitro rat hepatocytes.Results: The study showed that there was a significant increase in activity with respect to the increased concentration of extracts. Slight effect was observed in the isolated rat hepatocytes culture, M. koenigii leaves extract may exert cytoprotective and hypoglycemic action.Conclusion: It may be needed to determine the effect of ex vivo rat hepatocytes isolated from diabetic rats. Effects of the plant or isolated compounds on the genes expression of signaling pathways should be investigated in further studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::740835acec5a6aa9f6607323e54f3c48 https://doi.org/10.22159/ajpcr.2018.v11i11.27962 Zobrazit plný text záznamu