Gold nanoparticle-incorporated core and shell crosslinked micelles fabricated from thermoresponsive block copolymer ofN-isopropylacrylamide and a novel primary-amine containing monomer

Autor: Shiyong Liu, Yueming Zhou, Yaqiong Chen, Kunqiang Jiang
Rok vydání: 2008
Předmět:
Zdroj: Journal of Polymer Science Part A: Polymer Chemistry. 46:6518-6531
ISSN: 1099-0518
0887-624X
Popis: A novel primary amine-containing monomer, 1-(3′-aminopropyl)-4-acrylamido-1,2,3-triazole hydrochloride (APAT), was prepared from N-propargylacrylamide and 3-azidopropylamine hydrochloride via copper-catalyzed Huisgen 1,3-dipolar cycloaddition (click reaction). Poly(N-isopropylacrylamide)-b-poly(1-(3′-aminopropyl)-4-acrylamido-1,2,3-triazole hydrochloride), PNIPAM-b-PAPAT, was then synthesized via consecutive reversible addition-fragmentation chain transfer polymerizations of N-isopropylacrylamide and APAT. In aqueous solution, the obtained thermoresponsive double hydrophilic block copolymer dissolves molecularly at room temperature and self-assembles into micelles with PNIPAM cores and PAPAT shells at elevated temperature. Because of the presence of highly reactive primary amine moieties in PAPAT block, two types of covalently stabilized nanoparticles namely core crosslinked and shell crosslinked micelles with ‘inverted’ core-shell nanostructures were facilely prepared upon the addition of glutaric dialdehyde at 25 and 50 °C, respectively. In addition, the obtained structure-fixed micelles were incorporated with gold nanoparticles via in situ reduction of preferentially loaded HAuCl4. High resolution transmission electron microscopy revealed that gold nanoparticles can be selectively loaded into the crosslinked cores or shells, depending on the micelle templates employed. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 6518–6531, 2008
Databáze: OpenAIRE
Externí odkaz: